A lifelong of medication and lifestyle changes may be a thing of the past, soon. Researchers from the University of California developed a drug that may do a reversal for Type 2 Diabetes. The diabetes treatment makes use of the inhibition of an enzyme called LMPTP to restore the insulin sensitivity of diabetics.
The drug inhibits an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which is suspected to contribute to the reduction in cell sensitivity to insulin. With reduced LMPTP activity, the drug reenables insulin receptors on the surface of cells — particularly those in the liver — which in turn restores the cell’s ability to regulate excess sugar. When the body can once again regulate blood sugar levels, the condition of Type 2 diabetes is effectively reversed.
They studied mice that are fed a high-fat diet, which, due to obesity, developed high blood sugar levels. The rodent is then given a daily dosage of the drug that constrains the enzyme called low molecular weight protein tyrosine phosphatase (LMPTP). With the drug, diabetes reversal can be achieved as the reduction of LMPTP can restore the cell’s function.
Read more here.